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cpu-architecture

Mentors and Regional Facilitators
Name Region Skills Interests
Adam Carlson Campus Champions
Charles Forsyth Campus Champions
Cody Stevens Campus Champions, CCMNet
Chris Reidy Campus Champions, CCMNet
Deborah Penchoff Campus Champions
Jeff Falgout Campus Champions, RMACC
Julie Ma ACCESS CSSN, At-Large, Campus Champions, CAREERS, CCMNet, Northeast
James Hutcheson Campus Champions, ACCESS CSSN
Michael Schnaitter ACCESS CSSN
Ron Rahaman Campus Champions
Ruben Lara Campus Champions
Liwen Shih Campus Champions, ACCESS CSSN
Steven Kuhlo TRECIS
Thomas Pranzatelli
Trey Breckenridge Campus Champions
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Engagements

Re-engineering Lilly’s KisunlaTM into a novel antibody targeting IL13RA2 against GBM using AI-driven macromolecular modeling
Atrium Health Levine Cancer
  • Summary and objectives of the proposed experiments: 
  1. An initial research-based Ab (scFv47, discovered by our collaborator Dr. Balyasnikova) model, modeling Ab-Ag (IL13RA2 against GBM) protein complex, and identifying the binding sites (epitopes) using ROSETTA and AlphaFold2 multimer tools.
  2. Graft the CDRs of scFv (single-chain variable fragment) of antibody or Bispecific T cell engagers (BTEs) onto the template Ab, the framework of Lilly's Kisunla™ Ab drug.
  3. Modify, improve, and optimize the overall or full antibody protein structures using AI-driven macromolecule modeling (AlphaFold3).
  4. Explore single nucleotide polymorphism (SNP), pathogenic genetic variants and N-glycosylation of IL13RA2 (target) protein domain interacting with the Ab candidates among the patient population using ROSETTA software packages.
Status: In Progress

People with Expertise

Deborah Penchoff

University of Tennessee - Knoxville

Programs

Campus Champions

Roles

research computing facilitator

Placeholder headshot

Expertise

Ron Rahaman

Georgia Institute of Technology

Programs

Campus Champions

Roles

research software engineer

Ronald Rahaman

Expertise

Cody Stevens

Wake Forest University

Programs

Campus Champions, CCMNet

Roles

regional facilitator, researcher/educator, research computing facilitator, ci systems engineer, CCMNet

Cody Stevens

Expertise

People with Interest

Alexandra Lamtyugina

University of Chicago

Programs

ACCESS CSSN

Roles

student-facilitator

Photo of Alexandra Lamtyugina

Interests

Nihar Biradar

Rutgers University

Programs

CAREERS

Roles

student-facilitator

Profile Photo

Interests

Morgan Newton

Santa Monica College

Programs

ACCESS CSSN

Roles

student-facilitator

Picture of Morgan Newton

Interests